If you have a cat, you know that they can go outside the box on occasion, and it can be challenging to remove the odors once they set in. Enzyme cleaners work well to remove smells by destroying the organic material that creates them. However, with so many different enzyme cleaners available, it can be challenging to find a brand that is non-toxic and effective at removing scents. We have chosen several different kinds to review for you so you can see the difference between them. We’ll give you the pros and cons of each one and tell you how they worked in our home. Keep reading while we look at package size, ingredients, effectiveness, and more to help you make an educated purchase.
A Quick Comparison of the 2023 Winners
Image Product Details
Best Overall
Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray
No mixing required
Dissolves stains and removes odors
Works for other scents like feces and vomit
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Best Value
PetSafe Wee Care Enzyme Cleaner
Safe to use around children and pets
Multi-surface cleaner
Eco-friendly
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R&R Stain & Odor Eliminator
Safe to use around children and pets
Multi-surface cleaner
Freshens fabric
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MisterMax Anti-Icky-Poo
Non-toxic
Multi-surface cleaner
Available in multiple sizes
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Nature’s Miracle Stain Remover
Odor locking technology
Eliminates deep-set in odors
No rinsing
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The 8 Best Urine, Odor & Stain Removers
- Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray – Best Overall
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Size: 32 oz
Fragrance: Neutral
Our Hepper’s Advanced Bio-Enzyme Pet Stain and Odor Eliminator formula is our pick as the best overall cat urine odor remover. Our spray is an extremely effective and eco-conscious product that works to bind, lift, and remove even the most offensive urine smells. The bio-enzymatic formula isn’t just for cat urine, either. You can use it on drool, vomit, feces, and other substances, too. This spray is simple to use. There’s no need to mix it with water. You just shake the bottle and spray it on the soiled area. The bio-enzymes will get to work right away to penetrate the area to both dissolve the stain and remove the odor at its source.
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Size: 32 oz
Fragrance: Neutral
This cleaning spray is tough on stains and odors but won’t harm the surfaces in your home. It has been tested on carpets, flooring, fabrics, and furniture. Of course, you’ll want to perform a colorfastness test to be sure, but we loved how versatile this formula is.
Another attractive feature of this spray is its neutral scent. Other odor eliminators on the market claim to remove odors at the source but instead just mask them with overpowering scents in their formulas. Our spray, however, is void of any chemical fragrances so when the urine smell is gone, you know it’s gone for good and not just hiding behind perfumes.
At Pet Keen, we’ve admired Hepper for many years and decided to take a controlling ownership interest so that we could benefit from the outstanding designs of this cool cat company!
Pros
No mixing required
Dissolves stains and removes odors
100% satisfaction guarantee
Affordable price tag
Works for other scents like feces and vomit
Cons
Product has to sit on stain for an hour or more to work effectively
- PetSafe Pet Loo Wee Care Enzyme Cleaner – Best Value
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Size: 16 ounces
Fragrance: No Fragrance
PetSafe Pet Loo Wee Care Enzyme Cleaner is our pick as the best value cat urine and odor remover. It’s safe to use around children and other pets and is also safe for the environment. It works on multiple surfaces and contains no fragrance, so it’s perfect for people with sensitivities.
No mixing required
Dissolves stains and removes odors
100% satisfaction guarantee
Affordable price tag
Works for other scents like feces and vomit
- No mixing required
- Dissolves stains and removes odors
- 100% satisfaction guarantee
- Affordable price tag
- Works for other scents like feces and vomit
Product has to sit on stain for an hour or more to work effectively
- Product has to sit on stain for an hour or more to work effectively
Size: 16 ounces
Fragrance: No Fragrance
We found that PetSafe Pet Loo Wee Care Enzyme Cleaner works well, but the small bottle runs out quickly.
Pros
Safe to use around children and pets
Multi-surface cleaner
Eco friendly
Cons
Might discolor fabric
Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator is another great premium choice. It is a non-toxic cleaner that is safe to use around children and pets, and it has a nice odor that will leave your room smelling better. You can use it on multiple surfaces like fabric, carpet, and furniture, and it’s easy to apply using the handy spray bottle.
Safe to use around children and pets
Multi-surface cleaner
Eco friendly
- Safe to use around children and pets
- Multi-surface cleaner
- Eco friendly
Might discolor fabric
- Might discolor fabric
Size: 1 quart
Fragrance: Yes
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The only negative things we can say about Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator was that it didn’t prevent our cats from returning to the same place we had already cleaned, and the container was flimsy and tended to leak., so we lost a lot of product.
Pros
Safe to use around children and pets
Multi-surface cleaner
Freshens fabric
Cons
Leaky bottle
MisterMax Anti-Icky-Poo is a great carpet cleaner for cat urine. This brand is available in many sizes up to one gallon, and you can purchase it scented or unscented. It’s non-toxic and safe to use around children and pets, and you can use it on all surfaces. We found it especially useful on the carpet because you can treat a large area.
Safe to use around children and pets
Multi-surface cleaner
Freshens fabric
- Safe to use around children and pets
- Multi-surface cleaner
- Freshens fabric
Leaky bottle
- Leaky bottle
Size: 1 quart
Fragrance: Scented and unscented
While enzymes often require more than one treatment to eliminate everything, we found MisterMax Anti-Icky-Poo to take more applications than the ones we looked at so far.
Pros
Non-toxic
Multi-surface cleaner
Available in multiple sizes
Cons
Requires multiple applications
Nature’s Miracle Dual Action Hard Floor Stain & Odor Remover is a great enzymatic urine remover. We found that its odor-locking technology does an excellent job of getting rid of urine odors and is has a special formula that works well on hard surfaces like concrete, brick, tile, and more, where other brands can struggle. The convenient spray bottle makes it easy to apply, and there is no need for rinsing.
Non-toxic
Multi-surface cleaner
Available in multiple sizes
- Non-toxic
- Multi-surface cleaner
- Available in multiple sizes
Requires multiple applications
- Requires multiple applications
Size: 24 ounce
Fragrance: Yes
The downside to Nature’s Miracle is that it contains a fragrance that we didn’t like, and we think many people will agree that it smells bad, and though it does an excellent job cleaning, our cats still return to the same spot to urinate again.
Pros
Odor locking technology
Eliminates deep-set in odors
No rinsing
Cons
Smells bad
Cats return to the same spot
You might also be interested in: 10 Natural and Safe Home Remedies to Keep Cats Away
Odor locking technology
Eliminates deep-set in odors
No rinsing
- Odor locking technology
- Eliminates deep-set in odors
- No rinsing
Smells bad
Cats return to the same spot
- Smells bad
- Cats return to the same spot
Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula is another decent cat urine and odor remover. It uses both bacteria and enzymes to help destroy organic material and odors. It’s non-toxic and safe to use around children and pets. It uses a special formula that works on multiple surfaces, including carpets, upholstery, bedding, clothing, and more.
Size: 1 quart
Fragrance: Unscented
The downside to Simple Solution Pet Stain & Odor is that it can take more than one application to remove the urine smell.
Pros
Bacteria and enzymes
Safe to use around children and pets
Designed for use on multiple surfaces
Cons
It doesn’t always get out the urine smell
- Nature’s Miracle Cat Urine Destroyer
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Size: 1 gallon
Fragrance: Yes
Nature’s Miracle Cat Enzymatic Urine Destroyer is a really good option for removing cat urine from carpets. It comes in a large 1-gallon container so that you won’t run out in the middle of a job. It can remove deep-set stains and starts to work almost immediately while remaining safe to use around children and pets. We noticed a difference just a few minutes after applying it.
Bacteria and enzymes
Safe to use around children and pets
Designed for use on multiple surfaces
- Bacteria and enzymes
- Safe to use around children and pets
- Designed for use on multiple surfaces
It doesn’t always get out the urine smell
- It doesn’t always get out the urine smell
Size: 1 gallon
Fragrance: Yes
The biggest downside to Nature’s Miracle Cat Enzymatic Urine Destroyer is that it leaves a powerful smell that fills the room. It also lingers for several days, and some people might not like it. It works well, but due to the fragrance, we only use it on big accidents.
Pros
Multi-surface cleaner
Works quickly
Eliminates set stains
Cons
Powerful smell
Simple Solution Yard Odor Away is our pick as the best urine remover for yards. It features a very easy-to-use design that allows you to connect the container directly to your garden hose for the perfect mix. Each 32-ounce container can control odors over 25,000 square feet, more than enough for most homes. You can also use it on other surfaces like your porch, deck, sidewalks, and lawn furniture.
Multi-surface cleaner
Works quickly
Eliminates set stains
- Multi-surface cleaner
- Works quickly
- Eliminates set stains
Powerful smell
- Powerful smell
The downside to Simple Solution is that it contains mild detergents that can irritate the eyes, so we can’t recommend using it around pets or children. Since the container only connects to the garden hose, it’s strictly for outdoor use.
Pros
Treats up to 25,000 square feet
Easy to use
Multi-surface
Cons
Contains detergent
Not for use around pets
Related Read: How to Get Cat Pee Smell Out of a Couch (3 Quick & Easy Methods)
Treats up to 25,000 square feet
Easy to use
Multi-surface
- Treats up to 25,000 square feet
- Easy to use
- Multi-surface
Contains detergent
Not for use around pets
- Contains detergent
- Not for use around pets
Buyer’s Guide: How to Select the Best Cat Urine, Odor & Stain Remover
What Are Enzyme Cleaners?
Enzymes are helpful bacteria that consume starch, oil, fat, protein, and other organic matter. While not all strains contain these elements, many of them do, and enzyme cleaners can help break them down, removing stains that would not be possible with traditional detergents. The slow breakdown of organic material is the source of many foul odors found in the home, and enzyme cleaners can help remove them.
What Can You Clean with Enzyme Cleaners?
Enzyme cleaners work perfectly for removing urine, feces, vomit, blood, and anything else that comes from a living thing. It also works well to remove food stains and sometimes removes the most difficult stains, like wine and blood. Enzyme cleaners also work well to eliminate grease and oil, and many restaurants use them in their floor cleaners.
Is There a Downside to Enzyme Cleaners?
Can Eat Away at Some Surfaces
The downside to enzyme cleaners is that they can eat away at certain surfaces if used too frequently. For instance, restaurants that use enzymes daily will notice that they can eat away at the grout between tiles, so it might not be a great choice for a floor with many small tiles. However, the process is extremely slow and only a concern if you are applying the enzymes several times a day for a long period.
Works Slowly
Most people expect to apply a product, rub it around a little, wipe it up, and have a clean surface, but that isn’t how enzymes work. Enzymes are living bacteria that spend their lives snacking on your stain. It takes time for them to eat it, and they may die before they finish because they have a relatively short lifespan.
With enzymes, you apply them and keep checking back every few hours. The stain should fade, and you will need to reapply it every 24 hours until it’s gone.
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What Is the Benefit of Enzyme Cleaners?
Many stains can penetrate the fabric and become locked, unable to be dislodged by traditional detergents. These detergents frequently contain chemicals that can be harmful to your pet or yourself. Enzymes, on the other hand, are microscopic living bacteria that will eat the stain before dying. These bacteria are not harmful to people or pets, and they have a short lifespan. They don’t create any odor or leave any residue behind that you need to rinse.
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See also: 10 Best Pet Stain Removers – Reviews & Top Picks
What Makes One Brand Better Than Another?
The primary thing that makes one brand better than another is the concentration of enzymes in the bottle. As the enzymes eat, they die, so if there are only a few, you will need to reapply it several times before your stain comes out. Unfortunately, there is no way to tell how concentrated most brands are, so you will need to resort to trial and error and reviews like these. Since many brands have limited ingredients, you can often guess the concentration based on cost.
You might also be interested in: Cat Peeing Outside Litter Box? 11 Reasons and How to Stop It
Conclusion
When choosing your next enzyme cleaner, we highly recommend our pick as the best overall. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray provides you with a highly versatile enzyme cleaner. The no-mix solution is more than suitable for most pet owners that have new or set-in accidents that require immediate clean-up. If your pet rarely has an accident and you are looking for something small for a single accident, we recommend our pick for the best value. The PetSafe Pet Loo Wee Care Enzyme Cleaner comes in a small eco-friendly package and should eliminate your stain or odor without breaking the bank.
We hope you have enjoyed reading over these reviews and found them helpful in answering your questions. If you have found a few brands you would like to try, please share these seven best cat urine and odor removers on Facebook and Twitter.
Featured Image Credit: y_seki, Shutterstock
